Research Associate in Human Regulatory T Cell Immunology

Job summary

The purpose of the post is to recruit a passionate, self-motivated and dynamic postdoctoral Research Associate to join Dr. Dominguez-Villar’s laboratory at Imperial College London, UK. Our research focuses on understanding the molecular mechanisms that maintain human regulatory T cell identity and plasticity and the regulation of CD4+ T cell responses in autoimmune and infectious disease settings. We have recently defined key signalling…

Job listing information

  • Reference MED00940
  • Date posted 7 December 2018
  • Closing date 18 January 2019
  • LocationSt Mary’s Campus(map)
  • Position typeFull time, fixed term
  • Salary£37,904 – £45,547 plus benefits
  • Department Department of Medicine
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

The purpose of the post is to recruit a passionate, self-motivated and dynamic postdoctoral Research Associate to join Dr. Dominguez-Villar’s laboratory at Imperial College London, UK. Our research focuses on understanding the molecular mechanisms that maintain human regulatory T cell identity and plasticity and the regulation of CD4+ T cell responses in autoimmune and infectious disease settings.

We have recently defined key signalling pathways underlying human Treg plasticity and acquisition of a Th1-like effector phenotype (Nat Immunol 2018;19:665, Cell Mol Life Sci 2017;74:4059, EMBO Rep 2016;17:1169). The successful candidate will examine the role of specific signalling pathways in maintaining Treg identity and modulating plasticity, and the role of environmental factors in activating/inhibiting them, with application to autoimmune diseases. This is a highly translational research project that will involve human samples from healthy individuals and patients, and might involve in vivo models of autoimmunity. The successful candidate will have a strong human molecular immunology background and experience in human immunology and related techniques. Flow cytometry, culture of primary T cells and Tregs, as well as molecular biology techniques are essential skills for applicants to be considered. Experience with in vivo models of autoimmunity and bioinformatics skills are desired but not required.

Duties and responsibilities

You will be responsible for designing, performing and analysing experiments, and share findings with colleagues.

You will help supervise students as needed.

You will be responsible for identifying and optimizing new techniques for the collection and analysis of data

You will write reports for submission to funding agencies, and manuscripts for submission to peer-review journals.

Essential requirements

– PhD in molecular or cellular immunology with experience in human immunology.
– Expertise in Treg and T cell cultures.
– Techniques required: flow cytometry, molecular biology techniques (DNA, RNA isolation, gene expression analysis, gene silencing/overexpression,, plasmid isolation, ChIP-seq)
– Statistical analysis of data
– Willingness to work as part of a team, to collaborate and help other colleagues when necessary.
– Excellent verbal and written communication skills.

Further information

Full-time, fixed term for 2 years in the first instance

Should you require any further details on the role please contact Dr. Margarita Dominguez-Villar (m.dominguez-villar@imperial.ac.uk).

For queries regarding the recruitment process please contact Daisy Alasya-Wade (d.alasya-wade@imperial.ac.uk).

For technical issues when applying online please email recruitment@imperial.ac.uk.

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations:

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

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