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A NIH-funded postdoctoral position within the Department of Immunology and Microbiology at the Scripps Research Institute, Florida campus, is available to study nuclear receptor (NR)-mediated transcriptional control of CD4+ T helper cell populations in the context of autoimmunity and chronic inflammation.

The candidates will develop new and use currently available strains of reporter and gene-deficient mice to examine how specific nuclear receptors mediate autoimmunity and chronic inflammatory diseases. These genetic tools will be combined with NR-selective small molecules that we have developed to discover and dissect the transcriptional circuitry of CD4+ T cell differentiation both in vitro and in vivo.

This project is multidisciplinary using a variety of techniques and approaches including mouse genetics, molecular biology techniques, chemical biology, immunology, and genomics. Incorporation of proteomics is also envisioned.

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About Scripps Research Institute

The Scripps Research Institute (TSRI) — one of the world’s largest, private, non-profit research organizations — stands at the forefront of basic biomedical science, a vital segment of medical research that seeks to comprehend the most fundamental processes of life. Over the last decades, the institute has established a lengthy track record of major contributions to the betterment of health and the human condition.