The College of Engineering has a postdoctoral position available at Virginia Commonwealth University in the Chemical and Life Sciences Engineering Department. VCU, in collaboration with MIT has received funding from DARPA to undertake a novel continuous process for the production of the antibiotic, Ciprofloxacin from starting materials through to finished formulated product. This project offers the unique opportunity to participate in a regulatory filing for the first ever continuous process from registered API starting materials to formulated product. The project will utilize the recently publicized Pharmacy on Demand platform developed at MIT to enable the first aNDA filing for such a continuous process.
The research project will involve the formulation process development, reaction engineering, process understanding and experimental protocols required to demonstrate understanding and control of the process. This opportunity offers the post-doctoral scholar a unique training opportunity which will be difficult to obtain elsewhere, namely working across the pharmaceutical chemistry, physical properties, and formulation technologies space, to develop a control strategy for a continuous process destined for a regulatory filing.
The formulation scientist will be responsible, working with our experienced consultants, for ensuring the formulation is robust and delivers a quality product. The successful candidate will be responsible for developing a QbD process and regulatory filing based on process analytical technology (PAT) techniques as well as parametric data collected from the tableting platform. He/She will also be responsible for developing RTD models and other predictive technologies to ensure that the process is under control.
The successful applicant will need to be interested with mentoring and supporting graduate and undergraduate students and have the skills to do so, as well as work in collaboration with a larger and more diverse group of scientists that make up our Pharmacy on Demand project structure.