We are working on live attenuated rubella vaccine as a novel viral vector. We have found that rubella vectors can express a variety of vaccine antigens. These include proteins from other viruses, as well as non-viral antigens and even self- antigens. CBER has a monkey colony, which is available for our work. The new vectors grow well in rhesus macaques, and they are quite immunogenic. We are working to determine which new antigens can be expressed and where they will be the most useful. Examples include HIV or SIV Gag, and malaria CSP protein. In the case of SIV, the overlapping host range in rhesus macaques provides a model for judging rubella vector immunogenicity and protection against SIV infection. In another case, we can infect macaques with SIV and then use rubella vectors as immunotherapy to cure the infection.
Requires PhD or MD degree.
Please provide CV and 3 references to firstname.lastname@example.org. Application date: ASAP to start work Sept 1, 2019.
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About NIH Office of Intramural Training & Education (OITE)
The NIH Office of Intramural Training & Education (OITE) is a division of the Office of Intramural Research (OIR), Office of the Director (OD). Our mission is to enhance the training experience of students and fellows on all of the NIH campuses. We work closely with the Training Offices in the NIH Institutes and Centers to help trainees in the Intramural Research Program (IRP). The intramural program is the sum of all the research projects carried out by NIH investigators and trainees in NIH facilities) develop scientific and professional skills that will enable them to become leaders in the biomedical research community.